GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4665809 | 1 | rs6720314 | chr2:26334852 | HADHA | chr2:26413505-26467594:- | -0.17 | -3.58 | 0.000375 | Gut microbiome composition (summer) |
| THCA | cis | rs12762955 | 1 | rs67205460 | chr10:1090366 | IDI2 | chr10:1064847-1071799:- | -0.24 | -3.46 | 0.000597 | Response to angiotensin II receptor blocker therapy |
| THCA | cis | rs1398024 | 1 | rs67207208 | chr10:23665914 | C10orf67 | chr10:23605521-23633772:- | -0.24 | -4.72 | 3.12E-6 | Crohn's disease and sarcoidosis (combined) |
| THCA | cis | rs7589728 | 1 | rs6720809 | chr2:88528943 | KRCC1 | chr2:88326724-88355248:- | -0.25 | -4.05 | 5.99E-5 | Plasma clusterin levels |
| THCA | cis | rs7589728 | 1 | rs6720809 | chr2:88528943 | THNSL2 | chr2:88469835-88486145:+ | -0.62 | -7.83 | 3.22E-14 | Plasma clusterin levels |
| THCA | cis | rs994533 | 1 | rs6720977 | chr2:218273375 | DIRC3 | chr2:218148748-218621316:- | 0.22 | 5.14 | 3.91E-7 | Height |
| THCA | cis | rs994533 | 1 | rs6721000 | chr2:218273453 | DIRC3 | chr2:218148748-218621316:- | 0.22 | 5.14 | 3.91E-7 | Height |
| THCA | cis | rs237743 | 1 | rs67214274 | chr20:47898561 | DDX27 | chr20:47835832-47860612:+ | 0.27 | 4.94 | 1.06E-6 | Height |
| THCA | cis | rs7586604 | 1 | rs6721652 | chr2:100377321 | TSGA10 | chr2:99613725-99771187:- | 0.17 | 3.36 | 0.000843 | Cannabis dependence |
| THCA | cis | rs672203 | 1 | rs672203 | chr1:70887099 | ZRANB2 | chr1:71528975-71546745:- | -0.11 | -3.35 | 0.000864 | Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) |
| THCA | cis | rs7589728 | 1 | rs6722069 | chr2:88533151 | KRCC1 | chr2:88326724-88355248:- | -0.25 | -3.86 | 0.000128 | Plasma clusterin levels |
| THCA | cis | rs7589728 | 1 | rs6722069 | chr2:88533151 | THNSL2 | chr2:88469835-88486145:+ | -0.63 | -7.82 | 3.32E-14 | Plasma clusterin levels |
| THCA | cis | rs962856 | 1 | rs6722203 | chr2:67569193 | ETAA1 | chr2:67624442-67637533:+ | -0.17 | -4.07 | 5.6E-5 | Pancreatic cancer |
| THCA | cis | rs7582720 | 1 | rs6722332 | chr2:203745327 | ALS2CR8 | chr2:203776978-203851060:+ | -0.29 | -5.93 | 5.93E-9 | Coronary artery disease or large artery stroke;Coronary artery disease or ischemic stroke |
| THCA | cis | rs7582720 | 1 | rs6722332 | chr2:203745327 | ICA1L | chr2:203637873-203736371:- | 0.25 | 4.18 | 3.49E-5 | Coronary artery disease or large artery stroke;Coronary artery disease or ischemic stroke |